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| Status |
Public on Sep 25, 2019 |
| Title |
Oral dosing for antenatal corticosteroids in the rhesus macaque |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: Evaluated the transcriptional effects of an effective oral dosing of antental corticosteroids using betamethasone-phophate compared to the clinical treatment with the combination drug betamethasone-phosphate+betamethasone-acetate for fetal lung maturation.
Methods: RNA-sequencing of the fetal hippocampus, liver and lung was done. Differential expression analysis was done using read counts.
Results: There were no significant differences between oral Beta-P and the clinical treatment in the fetal hippocampus. Small differences were detected in the fetal lung associated with cellular proliferation and in the fetal liver.
Conclusions: Oral betamethasone-phosphate is an effective oral treatment that does not cause toxic effect in the fetal brain despite the higher dose.
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| Overall design |
Time-pregnant rhesus macaques received corticosteroid treatments or placebo 5 days prior to delivery at 80% gestation.
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| Contributor(s) |
Schmidt AF, Kemp MW, Milad M, Miller LA, Bridges JP, Clarke MW, Kannan PS, Jobe AH |
| Citation(s) |
31536601 |
| Submission date |
May 14, 2019 |
| Last update date |
Sep 25, 2019 |
| Contact name |
Augusto F Schmidt |
| E-mail(s) |
aschmidt@med.miami.edu
|
| Phone |
3052430156
|
| Organization name |
University of Miami Miller School of Medicine
|
| Street address |
1611 NW 12th ave
|
| City |
Miami |
| State/province |
FL |
| ZIP/Postal code |
33136 |
| Country |
USA |
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| Platforms (1) |
| GPL14954 |
Illumina HiSeq 2000 (Macaca mulatta) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA542881 |
| SRA |
SRP198387 |
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