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Series GSE13213

Query DataSets for GSE13213

Status

Public on Jun 23, 2009

Title

Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

We identified a relapse-related molecular signature represented by 82 probes (RRS-82) through genome-wide expression profiling analysis of a training set of 60 patients. The robustness of RRS-82 in the selection of patients with a high probability of relapse was then validated with a completely blinded test set of 27 adenocarcinoma patients, showing a clear association of high risk RRS-82 with very poor patient prognosis regardless of disease stage. The discriminatory power of RRS-82 was further validated using an additional independent cohort of 30 Stage I patients who underwent surgery at a distinct period of time.

Keywords: Disease state analysis

Overall design

Expression profiles in 117 patients with lung adenocarcinomas.

Contributor(s)

Tomida S, Takeuchi T, Shimada Y, Arima C, Matsuo K, Mitsudomi T, Yatabe Y, Takahashi T

Citation(s)

19414676

Submission date

Oct 15, 2008

Last update date

Jan 23, 2019

Contact name

Takashi Takahashi

Organization name

Aichi Cancer Center

Street address

1-1 Kanokoden, Chikusa-ku

City

Nagoya

State/province

Aichi

ZIP/Postal code

464-8681

Country

Japan

Platforms (1)

GPL6480

Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)

Samples (117)

More...

GSM333673	Patient 001 with adenocarcinoma
GSM333674	Patient 002 with adenocarcinoma
GSM333675	Patient 003 with adenocarcinoma

GSM333676	Patient 004 with adenocarcinoma
GSM333677	Patient 005 with adenocarcinoma
GSM333678	Patient 006 with adenocarcinoma
GSM333679	Patient 007 with adenocarcinoma
GSM333680	Patient 008 with adenocarcinoma
GSM333681	Patient 009 with adenocarcinoma
GSM333682	Patient 010 with adenocarcinoma
GSM333683	Patient 011 with adenocarcinoma
GSM333684	Patient 012 with adenocarcinoma
GSM333685	Patient 013 with adenocarcinoma
GSM333686	Patient 014 with adenocarcinoma
GSM333687	Patient 015 with adenocarcinoma
GSM333688	Patient 016 with adenocarcinoma
GSM333689	Patient 018 with adenocarcinoma
GSM333690	Patient 019 with adenocarcinoma
GSM333691	Patient 020 with adenocarcinoma
GSM333692	Patient 021 with adenocarcinoma
GSM333693	Patient 023 with adenocarcinoma
GSM333694	Patient 024 with adenocarcinoma
GSM333695	Patient 025 with adenocarcinoma
GSM333696	Patient 026 with adenocarcinoma
GSM333697	Patient 027 with adenocarcinoma
GSM333698	Patient 029 with adenocarcinoma
GSM333699	Patient 030 with adenocarcinoma
GSM333700	Patient 031 with adenocarcinoma
GSM333701	Patient 032 with adenocarcinoma
GSM333702	Patient 033 with adenocarcinoma
GSM333703	Patient 034 with adenocarcinoma
GSM333704	Patient 035 with adenocarcinoma
GSM333705	Patient 036 with adenocarcinoma
GSM333706	Patient 037 with adenocarcinoma
GSM333707	Patient 038 with adenocarcinoma
GSM333708	Patient 039 with adenocarcinoma
GSM333709	Patient 040 with adenocarcinoma
GSM333710	Patient 041 with adenocarcinoma
GSM333711	Patient 042 with adenocarcinoma
GSM333712	Patient 043 with adenocarcinoma
GSM333713	Patient 044 with adenocarcinoma
GSM333714	Patient 045 with adenocarcinoma
GSM333715	Patient 046 with adenocarcinoma
GSM333716	Patient 047 with adenocarcinoma
GSM333717	Patient 048 with adenocarcinoma
GSM333718	Patient 049 with adenocarcinoma
GSM333719	Patient 050 with adenocarcinoma
GSM333720	Patient 051 with adenocarcinoma
GSM333721	Patient 052 with adenocarcinoma
GSM333722	Patient 053 with adenocarcinoma
GSM333723	Patient 054 with adenocarcinoma
GSM333724	Patient 055 with adenocarcinoma
GSM333725	Patient 056 with adenocarcinoma
GSM333726	Patient 057 with adenocarcinoma
GSM333727	Patient 058 with adenocarcinoma
GSM333728	Patient 059 with adenocarcinoma
GSM333729	Patient 060 with adenocarcinoma
GSM333730	Patient 061 with adenocarcinoma
GSM333731	Patient 062 with adenocarcinoma
GSM333732	Patient 063 with adenocarcinoma
GSM333733	Patient 064 with adenocarcinoma
GSM333734	Patient 065 with adenocarcinoma
GSM333735	Patient 066 with adenocarcinoma
GSM333736	Patient 067 with adenocarcinoma
GSM333737	Patient 068 with adenocarcinoma
GSM333738	Patient 069 with adenocarcinoma
GSM333739	Patient 070 with adenocarcinoma
GSM333740	Patient 071 with adenocarcinoma
GSM333741	Patient 072 with adenocarcinoma
GSM333742	Patient 073 with adenocarcinoma
GSM333743	Patient 074 with adenocarcinoma
GSM333744	Patient 075 with adenocarcinoma
GSM333745	Patient 076 with adenocarcinoma
GSM333746	Patient 077 with adenocarcinoma
GSM333747	Patient 078 with adenocarcinoma
GSM333748	Patient 079 with adenocarcinoma
GSM333749	Patient 080 with adenocarcinoma
GSM333750	Patient 081 with adenocarcinoma
GSM333751	Patient 082 with adenocarcinoma
GSM333752	Patient 083 with adenocarcinoma
GSM333753	Patient 084 with adenocarcinoma
GSM333754	Patient 085 with adenocarcinoma
GSM333755	Patient 086 with adenocarcinoma
GSM333756	Patient 087 with adenocarcinoma
GSM333757	Patient 088 with adenocarcinoma
GSM333758	Patient 089 with adenocarcinoma
GSM333759	Patient 090 with adenocarcinoma
GSM333760	Patient 101 with adenocarcinoma
GSM333761	Patient 102 with adenocarcinoma
GSM333762	Patient 103 with adenocarcinoma
GSM333763	Patient 104 with adenocarcinoma
GSM333764	Patient 105 with adenocarcinoma
GSM333765	Patient 106 with adenocarcinoma
GSM333766	Patient 107 with adenocarcinoma
GSM333767	Patient 108 with adenocarcinoma
GSM333768	Patient 109 with adenocarcinoma
GSM333769	Patient 110 with adenocarcinoma
GSM333770	Patient 111 with adenocarcinoma
GSM333771	Patient 112 with adenocarcinoma
GSM333772	Patient 113 with adenocarcinoma
GSM333773	Patient 114 with adenocarcinoma
GSM333774	Patient 115 with adenocarcinoma
GSM333775	Patient 116 with adenocarcinoma
GSM333776	Patient 117 with adenocarcinoma
GSM333777	Patient 118 with adenocarcinoma
GSM333778	Patient 119 with adenocarcinoma
GSM333779	Patient 120 with adenocarcinoma
GSM333780	Patient 121 with adenocarcinoma
GSM333781	Patient 122 with adenocarcinoma
GSM333782	Patient 123 with adenocarcinoma
GSM333783	Patient 124 with adenocarcinoma
GSM333784	Patient 125 with adenocarcinoma
GSM333785	Patient 126 with adenocarcinoma
GSM333786	Patient 127 with adenocarcinoma
GSM333787	Patient 128 with adenocarcinoma
GSM333788	Patient 129 with adenocarcinoma
GSM333789	Patient 130 with adenocarcinoma

Relations

Affiliated with

GSE67639

BioProject

PRJNA109445

Relapse-related molecular signature (RRS-82) header descriptions
ProbeID	Feature Number
GeneSymbol	Gene symbols
GeneName	Gene description
Accessions	Accession IDs for refseq, ensemble, genbank
Flag_23828	Flag for 23828 probes that passed the initial filtering
RRS-82	Flag for RRS-82 probes

Data table
ProbeID	GeneSymbol	GeneName	Accessions	Flag_23828	RRS-82
A_23_P100001	LOC400451	hypothetical gene supported by AK075564; BC060873	ref\|NM_207446\|ens\|ENST00000327355\|gb\|CR606671\|gb\|AK075564	1	0
A_23_P100011	AP3S2	adaptor-related protein complex 3, sigma 2 subunit	ref\|NM_005829\|ens\|ENST00000336418\|ens\|ENST00000357484\|ens\|ENST00000379137	0	0
A_23_P100022	SV2B	synaptic vesicle glycoprotein 2B	ref\|NM_014848\|ens\|ENST00000330276\|gb\|AB018278\|gb\|BC030011	1	0
A_23_P100056	RBPMS2	RNA binding protein with multiple splicing 2	ref\|NM_194272\|ens\|ENST00000300069\|gb\|AK127873\|gb\|AK124123	0	0
A_23_P100074	AVEN	apoptosis, caspase activation inhibitor	ref\|NM_020371\|ens\|ENST00000306730\|gb\|CR618548\|gb\|CR619789	1	0
A_23_P100092	ZNF690	zinc finger protein 690	ref\|NM_152455\|gb\|BC109270\|gb\|AK122788\|gb\|AK093377	1	0
A_23_P100103	VPS39	vacuolar protein sorting 39 (yeast)	ref\|NM_015289\|ens\|ENST00000318006\|ens\|ENST00000348544\|gb\|AF280814	1	0
A_23_P100111	CHP	calcium binding protein P22	ref\|NM_007236\|ens\|ENST00000334660\|gb\|BC051815\|gb\|BC031293	1	0
A_23_P100127	CASC5	cancer susceptibility candidate 5	ref\|NM_170589\|ref\|NM_144508\|gb\|AF248041\|ens\|ENST00000346991	1	0
A_23_P100133	ASCIZ	ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein	ref\|NM_015251\|ens\|ENST00000299575\|gb\|AB007891\|gb\|CR749457	1	0
A_23_P100141	C16orf28	chromosome 16 open reading frame 28	ref\|NM_023076\|gb\|AK022685\|gb\|AK027013\|ens\|ENST00000248104	1	0
A_23_P100156	TMEM127	transmembrane protein 127	ref\|NM_017849\|gb\|BC028575\|ens\|ENST00000258439\|gb\|AK025910	1	0
A_23_P100177	MMP15	matrix metallopeptidase 15 (membrane-inserted)	ref\|NM_002428\|gb\|BC036495\|ens\|ENST00000219271\|gb\|CR596713	0	0
A_23_P100189	PRM1	protamine 1	ref\|NM_002761\|ens\|ENST00000312511\|gb\|CR612045\|gb\|Y00443	0	0
A_23_P100196	USP10	ubiquitin specific peptidase 10	ref\|NM_005153\|gb\|CR749515\|ens\|ENST00000219473\|ens\|ENST00000378510	1	0
A_23_P100203	HSBP1	heat shock factor binding protein 1	ref\|NM_001537\|gb\|CR626052\|gb\|CR608180\|gb\|CR623333	1	0
A_23_P100220	RBM35B	RNA binding motif protein 35B	ref\|NM_024939\|gb\|BC030146\|gb\|AK025571\|ens\|ENST00000251366	1	0
A_23_P100240	CDH16	cadherin 16, KSP-cadherin	ref\|NM_004062\|gb\|AY358911\|ens\|ENST00000299752\|gb\|AK075243	0	0
A_23_P10025	NELL2	NEL-like 2 (chicken)	ref\|NM_006159\|ens\|ENST00000333837\|gb\|CR598058\|gb\|CR606928	1	0
A_23_P100263	CMIP	c-Maf-inducing protein	ref\|NM_198390\|ref\|NM_030629\|gb\|BC038113\|gb\|AB051481	1	0

Total number of rows: 41000

Table truncated, full table size 3819 Kbytes.

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE13213_AD117_patient_info.txt	7.6 Kb	(ftp)(http)	TXT
GSE13213_RAW.tar	1.6 Gb	(http)(custom)	TAR (of TXT)
Processed data included within Sample table