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| Status |
Public on Jun 08, 2022 |
| Title |
Genome-wide screen unveils the synthetic lethality targets of mitomycin C |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
To dig out the synthetic lethality targets of mitomycin C, we we performed Genome-scale CRISPR-Cas9 knockout screening in SNU-1 with 0.1% DMSO or 0.3 µM MMC for 14 days. We found that BRCA2 is a synthetic lethality target of mitomycin C.
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| Overall design |
GeCKO Library screen in SNU-1 with vehicle or MMC for 14 days.
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| Contributor(s) |
Chen X, Lang J |
| Citation missing |
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| Submission date |
Jun 10, 2019 |
| Last update date |
Jun 08, 2022 |
| Contact name |
Jingyu Lang |
| E-mail(s) |
cscttlab@163.com
|
| Organization name |
Shanghai Institutes for Biological Sciences
|
| Street address |
320 Yueyang Road
|
| City |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
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| Platforms (1) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA548076 |
| SRA |
SRP200957 |
