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| Status |
Public on Jul 01, 2022 |
| Title |
BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The puropose of this study is to reveal a noncanonical post-transcriptional regulatory function of BRD4 that maintains cancer growth and dissemination, with immediate translational implication for treating metastatic malignancies with clinically available bromodomain inhibitors. The next-generation RNA sequencing was used to confirm the transcriptom overlapping change after BRD4 and Snail knockout separately.
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| Overall design |
mRNA profiles of gastric cancer cells which were generated by depletion of control, Snail and BRD4 were generated by deep sequencing, in triplicate, using Illumina hiseqxten .
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| |
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| Contributor(s) |
Qin Z, Wang B |
| Citation missing |
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| Submission date |
Jul 11, 2019 |
| Last update date |
Jul 01, 2022 |
| Contact name |
Zhon-gyi qin |
| E-mail(s) |
docqin_tmmu@126.com
|
| Phone |
+8618623657877
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| Organization name |
Daping Hospital, Army Military Medical University (Third Military Medical University)
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| Department |
Gastroenterology
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| Street address |
Changjiang Road, Yuzhong District
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| City |
Chongqing |
| ZIP/Postal code |
400042 |
| Country |
China |
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| Platforms (1) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA554098 |
| SRA |
SRP214258 |
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