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| Status |
Public on Mar 03, 2024 |
| Title |
Maternal folic acid overconsumption in mice leads to sex-specific transcriptional alterations in cerebral cortex in offspring |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Recent concerns have been raised regarding high folate intake during pregnancy and lactation, particularly following food fortification and increased vitamin supplement use. Epidemiologic studies have shown that high folic acid (FA) intake can negatively impact motor and neurocognitive development in offspring.
We used microarray to investigate the mechanisms by which a supplemented diet containing 5-fold higher FA than recommended (FASD) affects brain function in both male and female offspring.
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| Overall design |
At weaning, wild-type C57BL/6 female mice were placed for a month on a control diet or a FASD, and then mated to study offspring. Diets were maintained throughout pregnancy and lactation. We conducted several behavioral tests on pups before sacrificing them at weaning. Brains were collected to conduct gene expression analysis by microarray using Affymetrix Clariom S array_Mouse Chip.
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| Contributor(s) |
Cosín-Tomás M, Luan Y, Leclerc D, Maleysheva O, Lauzon N, Bahous RH, Christensen K, Caudill M, Rozen R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 20, 2019 |
| Last update date |
Mar 03, 2024 |
| Contact name |
Marta Cosin Tomas |
| E-mail(s) |
marta.cosin@gmail.com
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| Organization name |
ISGlobal
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| Department |
Child Health and environment
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| Lab |
Prof. Jordi Sunyer
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| Street address |
Dr. Aiguader, 88
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| City |
Barcelona |
| State/province |
Spain |
| ZIP/Postal code |
08003 |
| Country |
Spain |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (14)
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| GSM3956512 |
Male whose mother was fed a control diet, biological replicate 1 |
| GSM3956513 |
Male whose mother was fed a control diet, biological replicate 2 |
| GSM3956514 |
Male whose mother was fed a control diet, biological replicate 3 |
| GSM3956515 |
Male whose mother was fed a control diet, biological replicate |
| GSM3956516 |
Male whose mother was fed a FASD diet, biological replicate 1 |
| GSM3956517 |
Male whose mother was fed a FASD diet, biological replicate 2 |
| GSM3956518 |
Male whose mother was fed a FASD diet, biological replicate 3 |
| GSM3956519 |
Male whose mother was fed a FASD diet, biological replicate 4 |
| GSM3956520 |
Female whose mother was fed a control diet, biological replicate 1 |
| GSM3956521 |
Female whose mother was fed a control diet, biological replicate 2 |
| GSM3956522 |
Female whose mother was fed a control diet, biological replicate 3 |
| GSM3956523 |
Female whose mother was fed a FASD diet, biological replicate 1 |
| GSM3956524 |
Female whose mother was fed a FASD diet, biological replicate 2 |
| GSM3956525 |
Female whose mother was fed a FASD diet, biological replicate 3 |
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| Relations |
| BioProject |
PRJNA555715 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE134588_RAW.tar |
14.4 Mb |
(http)(custom) |
TAR (of CEL) |
| GSE134588_microarray_processed_results.xlsx |
260.9 Kb |
(ftp)(http) |
XLSX |
| Processed data included within Sample table |
| Processed data are available on Series record |
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