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| Status |
Public on Dec 31, 2019 |
| Title |
miRNA Analysis of lungs of LCPUFA-treated asthmatic C57BL/6 mice and respective controls |
| Organisms |
Homo sapiens; Mus musculus; synthetic RNA |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Next generation sequencing (NGS) results demonstrate the modulative capacity of LCPUFAs on dysregulated miRNA expression in asthma.
Methods: Sequencing of miRNA was performed by NGS from lung tissue of asthmatic and control mice with normal diet, as well as of LCPUFA supplemented asthmatic mice using Illumina miSeq.
Conclusion: Our results demonstrate the modulative capacity of LCPUFAs on dysregulated miRNA expression in asthma.
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| Overall design |
Lungs of LCPUFA-treated asthmatic C57BL/6 mice and respective controls were analyzed with n=4-5 via NGS
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| Contributor(s) |
Fussbroich D, Kohnle C, Schwenger T, Driessler C, Dücker RP, Eickmeier O, Gottwald G, Jerkic S, Zielen S, Kreyenberg H, Beermann C, Chiocchetti A, Schubert R |
| Citation(s) |
31698144 |
| Submission date |
Aug 08, 2019 |
| Last update date |
Mar 31, 2020 |
| Contact name |
Daniela Fussbroich |
| E-mail(s) |
daniela.fussbroich@lt.hs-fulda.de
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| Organization name |
University of Applied Sciences Fulda
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| Street address |
Leipziger Str. 123
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| City |
Fulda |
| ZIP/Postal code |
36037 |
| Country |
Germany |
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| Platforms (3) |
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| Samples (16)
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| GSM4021782 |
Lung, HDM + Normal Diet (28) |
| GSM4021783 |
Lung, PBS + Normal Diet (43) |
| GSM4021784 |
Lung, PBS + Normal Diet (45) |
| GSM4021785 |
Lung, HDM + Normal Diet (46) |
| GSM4021786 |
Lung, HDM + Normal Diet (47) |
| GSM4021787 |
Lung, HDM + Normal Diet (48) |
| GSM4021788 |
Lung, HDM + MM (49) |
| GSM4021789 |
Lung, HDM + MM (50) |
| GSM4021790 |
Lung, HDM + MM (52) |
| GSM4021791 |
Lung, HDM + MM (53) |
| GSM4021792 |
Lung, HDM + MM (54) |
| GSM4021793 |
human brain Conrol |
| GSM4021794 |
miRNA Control |
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| Relations |
| BioProject |
PRJNA559388 |
| SRA |
SRP217862 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE135597_RAW.tar |
140.0 Kb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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