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| Status |
Public on Aug 15, 2020 |
| Title |
CTCF orchestrated enhancer hijacking accelerated tumorigenesis through remodeling 3D chromosomal architecture in NTS locus |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We identified aberrant CTCF binding lead to a 3D chromosomal interactional driver in NTS locus that accelerates tumorigenesis of uveal melanoma. Both enhancer deletion and abolishing CTCF binding lead to the loss of chromosomal looping and triggered therapeutic efficacy in inhibiting tumorigenesis. Our study shed light on a functional chromosomal architecture induced enhancer hijacking, thereby provide novel concept of 3D-chromosomal conformation exploration.
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| Overall design |
We performed microarray in 2 types of ocular melanoma cells with or without decoyed CTCF
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| |
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| Contributor(s) |
Chai P, Fan X |
| Citation missing |
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| Submission date |
Aug 22, 2019 |
| Last update date |
Aug 15, 2020 |
| Contact name |
Peiwei Chai |
| E-mail(s) |
chaipeiwei123@sjtu.edu.cn
|
| Organization name |
Shanghai Ninth people's hospital
|
| Department |
Opthalmology
|
| Street address |
No.833 Zhizaoju Road
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200011 |
| Country |
China |
| |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
|
| Samples (4)
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| Relations |
| BioProject |
PRJNA561607 |
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