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Series GSE138043 Query DataSets for GSE138043
Status Public on Nov 03, 2020
Title IDENTIFYING KEY DRIVER GENES OF INNATE IMMUNE PATHWAYS AS NOVEL THERAPEUTIC TARGETS IN RENAL ALLOGRAFT REJECTION
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Acute rejection (AR) in renal transplantation is an established risk factor for reduced allograft survival, and still occurs in 10-20% of allograft recipients despite standard of care immunosuppression. This suggests molecular pathways exist which are inadequately suppressed by current therapy. We describe for the first time, integrative network- based computational strategies incorporating genotyping data to identify key driver genes (KDGs) amongst networks of perturbed transcripts in AR, which may serve as therapeutic targets.
 
Overall design A microarray set (N=52) was used for discovery of meta-gene sigantures associated with acute rejection.
 
Contributor(s) Yi Z, Keung K, Zhang W, Murphy B
Citation(s) 32634125
Submission date Sep 26, 2019
Last update date Nov 05, 2020
Contact name Weijia Zhang
E-mail(s) weijia.zhang@mssm.edu
Organization name Icahn School of Medicine at Mount Sinai
Department Renal
Lab Bioinfomatics
Street address 1 Gustave L. Levy Pl
City New York
State/province NY
ZIP/Postal code 10029
Country USA
 
Platforms (1)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (52)
GSM4097336 P1
GSM4097337 P2
GSM4097338 P3
Relations
BioProject PRJNA574297

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138043_RAW.tar 1.1 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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