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| Status |
Public on Sep 17, 2020 |
| Title |
METTL5, an 18S rRNA-specific m6A methyltransferase, regulates the Integrated Stress Response [eCLIP] |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
RNA N6-methyladenosine (m6A) modification is present in different RNA molecules, including protein-coding mRNAs and non-coding RNAs such as ribosomal RNAs (rRNAs).Here, we report that mammalian METTL5, a member of a highly conserved methyltransferase family, specifically methylates adenosine 1832 (A1832) in the 18S rRNA in vivo and in vitro.
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| Overall design |
We used eCLIP-seq to identify the binding targets of METTL5 in human 293T cells.
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| Web link |
https://www.biorxiv.org/content/10.1101/2020.04.27.064162v2
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| Contributor(s) |
Chen H, Shi Y |
| Citation missing |
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| Submission date |
Sep 27, 2019 |
| Last update date |
Sep 17, 2020 |
| Contact name |
Yang Shi |
| Organization name |
BOSTON CHILDREN'S HOSPITAL
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| Department |
NEWBORN MEDICINE
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| Street address |
320 LONGWOOD AVE
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| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA574656 |
| SRA |
SRP223540 |
