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| Status |
Public on Mar 30, 2020 |
| Title |
Abrogation of esophageal carcinoma development by miR-31 genetic knockout |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptomics analyses in these Zn-deficient rats revealed the molecular basis of ESCC abrogation by miR-31 knockout: Egln3, a negative regulator of NF-FB, was shown to be a direct miR-31 target; miR-31 inhibition/deletion resulted in suppression of miR-31-associated-EGLN3-NF-KB controlled inflammatory pathways.
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| Overall design |
Genome-wide expression profiling and the analysis of genes with derepressed transcript levels in response to antimiR-31 delivery in vivo. The experimental design consist of rats that received antimirR over the 5 weeks (ZD-antimir31 5weeks), 20 weeks (ZD-antimir31 20 weeks) and untreated rats (ZD:CTRL, ZS: CTRL). Transcriptome profiling was also performed from group of rats with constitutive miR-31 KO (ZD-mir31KO, ZS-mir31KO).
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| Contributor(s) |
Fong LY, Taccioli C, Palamarchuk A, Tagliazucchi GM, Jing R, Smalley KJ, Fan S, Altemus J, Fiehn O, Huebner K, Farber JL, Croce CM |
| Citation(s) |
32123074 |
| Submission date |
Nov 11, 2019 |
| Last update date |
Mar 30, 2020 |
| Contact name |
Guidantonio Malagoli Tagliazucchi |
| Organization name |
Hospital of Parma
|
| Department |
Division of Research and Innovation
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| Street address |
Via Gramsci 14
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| City |
Parma |
| ZIP/Postal code |
43121 |
| Country |
Italy |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA588752 |
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