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| Status |
Public on Nov 16, 2019 |
| Title |
Transcriptome analysis of WT and TRIM28 KO CD4 T cells, naïve or stimulated with anti-CD3 (plate-bound) and anti-CD28 (soluble) in Th0, Th1, Th2, Th17 or Treg conditions |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Critical role for TRIM28 and HP1b/g in the epigenetic control of T cell metabolic reprogramming and effector differentiation
The study explores the role of gene silencing by TRIM28, an adaptor protein for histone binding modules , in CD4 T cell function.
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| Overall design |
Littermate and TRIM28KO CD4 T cells were sorted by flow cytometry, naïve or stimulated for 72h with anti-CD3 (plate-bound) and anti-CD28 (soluble) in Th0, Th1, Th2, Th17 or Treg conditions.
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| |
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| Contributor(s) |
Gehrmann U, Goudot C, Gentien D |
| Citation(s) |
31776254 |
| Submission date |
Nov 15, 2019 |
| Last update date |
Dec 31, 2019 |
| Contact name |
Sebastian Amigorena |
| Organization name |
Institut Curie
|
| Lab |
Inserm U932
|
| Street address |
26 rue D'ulm
|
| City |
Paris |
| ZIP/Postal code |
75005 |
| Country |
France |
| |
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| Platforms (1) |
| GPL17400 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (36)
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| This SubSeries is part of SuperSeries: |
| GSE140448 |
Critical role for TRIM28 and HP1beta/gamma in the epigenetic control of T cell metabolic reprograming and effector differentiation |
|
| Relations |
| BioProject |
PRJNA589772 |
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