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| Status |
Public on May 10, 2024 |
| Title |
Gene expression profiling of mouse CRTC1-MAML2-driven MEC-like tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
We established a transgenic CRTC1-MAML2 fusion mouse model and crossed it with the MMTV-Cre transgenic mouse line to induce Cre expression and consequently the CRTC1-MAML2 fusion transgene expression in salivary glands. We observed that Cre-induced CRTC1-MAML2 transgene expression caused the formation of salivary gland tumors resembling the histological features of human MEC. Here we performed genome-wide gene expression profiling analysis to characterize the transcriptomic feature of these murine CRTC1-MAML2-driven MEC-like tumors.
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| Overall design |
Gene expression profiling was carried out on CRTC1-MAML2-driven MEC-like tumors (T), matched tumor adjacent normal salivary gland tissues (NAT), and normal salivary gland tissues (N) from the control non-transgene carrier littermates (N). Differentially expressed genes (DEGs) were determined in three comparison groups, including NAT vs. N, T vs. NAT, and T vs. N.
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| Contributor(s) |
Wu L |
| Citation(s) |
33830080 |
| Submission date |
Jan 07, 2020 |
| Last update date |
May 11, 2024 |
| Contact name |
Lizi Wu |
| Organization name |
University of Florida
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| Street address |
2033 Mowry Road
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| City |
Gainesville |
| State/province |
FL |
| ZIP/Postal code |
32610 |
| Country |
USA |
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| Platforms (1) |
| GPL19286 |
Arraystar Mouse LncRNA microarray V3B (Agilent-055750 custom Probe Name version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA599424 |
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