|
| Status |
Public on Oct 01, 2020 |
| Title |
Identification of TGF-b targets in the cardiac outflow tract by transcriptomic analysis |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: identifying, with RNA-seq, genes targets of Alk5 during the development of the cardiac outflow tract in zebrafish. Results: we identified several differential expressed genes, with an enrichment in ECM component genes. As a proof of concept, many TGFb known targets also appeared downregulated.
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| |
|
| Overall design |
Zebrafish embryos were treated with Alk5 inhibitor E-616452 (or DMSO) and hearts were manually extracted at 56 hpf.
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| |
|
| Contributor(s) |
Boezio GL, Guenther S |
| Citation(s) |
32990594 |
| Submission date |
Jan 16, 2020 |
| Last update date |
Oct 06, 2020 |
| Contact name |
Stefan Günther |
| E-mail(s) |
stefan.guenther@mpi-bn.mpg.de
|
| Organization name |
MPI for heart and lung research
|
| Street address |
ludwigtr. 43
|
| City |
bad nauheim |
| ZIP/Postal code |
61231 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL20828 |
Illumina NextSeq 500 (Danio rerio) |
|
| Samples (4)
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| Relations |
| BioProject |
PRJNA601645 |
| SRA |
SRP242182 |
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