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| Status |
Public on Apr 18, 2020 |
| Title |
Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions [ClariomS] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Hippo kinases Mst1 and Mst2 act as molecular rheostats for the terminal maturation and effector differentiation programs of iNKT cells. Loss of Mst1 alone or with Mst2 impedes iNKT cell development, associated with defective IL-15-dependent cell survival
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| Overall design |
Microarray analysis of 6 Samples of WT iNKT cells from stage 1 and stage 2; 4 samples of Mst1 single KO from stage 1 and stage 2; 7 samples of WT iNKT from stage 3; 5 Samples of Mst1KO iNKT from stage 3; 2 samples of Mst1/2 double KO iNKT from stage 1 and stage 2; 1 sample of Mst1/2 double KO from stage 3 (total n = 25)
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| |
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| Contributor(s) |
Raynor J, Dhungana Y, Chi H |
| Citation(s) |
32289155 |
| Submission date |
Feb 04, 2020 |
| Last update date |
Jul 21, 2020 |
| Contact name |
Hongbo Chi |
| E-mail(s) |
hongbo.chi@stjude.org
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Immunology
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (25)
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| This SubSeries is part of SuperSeries: |
| GSE144778 |
Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions |
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| Relations |
| BioProject |
PRJNA604837 |
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