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| Status |
Public on Jun 09, 2022 |
| Title |
Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that culminates in right heart failure. Vascular pathology in PH is characterized by pulmonary vasoconstriction and progressive vascular remodeling processes that affects all layers of the vascular wall (intima, media and adventitia). Our objective was to profile and analyze the differential gene expression signatures between the cells isolated from normal and idiopathic PAH patients. We generated vascular cell-specific transcriptome profiles from the adventitial fibroblasts (PAAF) isolated ex vivo from the dissected human pulmonary arteries of normal donor and PAH lungs using paired-end RNA-sequencing.
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| Overall design |
Transcriptome profiling of pulmonary artery adventital fibroblasts (PAAF) isolated from 4 healthy donors and 4 PAH afflicted patients.
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| Contributor(s) |
Chelladurai P, Kuenne C, Weber C, Nötzold RR, Schmoranzer M, Günther S, Looso M, Bauer U, Seeger W, Pullamsetti SS |
| Citation(s) |
35675437 |
| Submission date |
Feb 07, 2020 |
| Last update date |
Jun 10, 2022 |
| Contact name |
Carsten Kuenne |
| E-mail(s) |
Carsten.Kuenne@mpi-bn.mpg.de
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| Organization name |
Max Planck Institute for Heart and Lung Research
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| Department |
Bioinformatics
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| Street address |
Ludwigstrasse 43
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| City |
Bad Nauheim |
| ZIP/Postal code |
61231 |
| Country |
Germany |
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| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
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| Samples (34)
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| This SubSeries is part of SuperSeries: |
| GSE144936 |
Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension |
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| Relations |
| BioProject |
PRJNA605369 |
| SRA |
SRP247635 |
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