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| Status |
Public on Feb 18, 2020 |
| Title |
Liver mRNA expression in high fat diet fed mice with hepatic specific Slug knockout |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Liver steatosis is a driving force for nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease, insulin resistance, and type 2 diabetes. Slug (also called Snai2 or Snail2) is a transcriptional regulator that may play a critical role in the regulation of liver function.
To prove that, we used microarrays to detail the hepatic Slug regulated gene expression underlying liver steatosis and identified distinct pathways controlled by Slug during this process.
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| Overall design |
C57BL/6J mice males with hepatic specific Slug knockout and their littermates were fed a high fat diet fed (HFD) for 11 weeks. Then RNA samples were extracted from the same parts of liver tissues and hybridizated on Affymetrix microarrays.
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| Web link |
https://www.ncbi.nlm.nih.gov/pubmed/32365055
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| |
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| Contributor(s) |
Liu Y, Rui L |
| Citation(s) |
32365055 |
| Submission date |
Feb 17, 2020 |
| Last update date |
May 19, 2020 |
| Contact name |
Liangyou Rui |
| E-mail(s) |
ruily@umich.edu
|
| Organization name |
University of Michigan
|
| Department |
Molecular and Integrative Physiology
|
| Street address |
1137 Catherine Street
|
| City |
Ann Arbor |
| State/province |
Michigan |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17400 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA607093 |
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