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Series GSE14556 Query DataSets for GSE14556
Status Public on May 10, 2011
Title Expression data from adult rat subventricular zone cells
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Transforming growth factor (TGF)-ß1 is a multifunctional cytokine regulating a number of physiological and patho-physiological processes in the adult brain. Its expression is elevated during neurodegeneration, which is associated with reduced levels of neurogenesis. We have postulated that TGF-ß1 might be one of the crucial factors involved in limiting neurogenesis in the diseased brain.

We used microarrays to detail the gene expression profile after TGFbeta-1 treatment and identified distinct classes of up- and downregulated genes.

Keywords: control versus TGFbeta1 treated group
 
Overall design Adult rat subventricular zone cells were cultured for 7 days under proliferation conditions. Control cells were exposed to HCl/BSA whereas TGFbeta-1 treated cells received 10 ng/ml TGFbeta-1 dissolved in HCl/BSA 3 times per week. RNA was extracted followed by hybridization on Affymetrix microarrays.
 
Contributor(s) Lehner B, Aigner L
Citation(s) 24779367
Submission date Jan 23, 2009
Last update date Aug 01, 2019
Contact name Dietrich Trümbach
E-mail(s) dietrich.truembach@helmholtz-muenchen.de
Organization name German Research Center for Environmental Health
Department Institute for Developmental Genetics
Street address Ingolstädter Landstraße 1
City München-Neuherberg
ZIP/Postal code 85764
Country Germany
 
Platforms (1)
GPL341 [RAE230A] Affymetrix Rat Expression 230A Array
Samples (2)
GSM364116 TGFbeta1
GSM364117 control
Relations
BioProject PRJNA111735

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE14556_RAW.tar 5.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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