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| Status |
Public on May 22, 2020 |
| Title |
Transcriptomic comparison between LGR5 and POLI double tumor cell populations in CRC |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
A transcriptomic comparative analysis was performed to explore and characterize in terms of gene expression and biological pathways the different LGR5 and POLI population from colorectal tumor xenografts.
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| Overall design |
Colorectal cancer tumor organoids were knocked-in with fluorescent reporters to label LGR5 and POLR1A populations. These modified organoids were injected and grown as subcutaneous tumor xenografts. Derived tumor were processed and the double LGR5 and POLI tumor cells populations (LGR5+/POL1high, LGR5+POL1low/LGR5-POL1high/LGR5-POL1low) were isolated and processed for transcirptomic analyses.
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| |
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| Contributor(s) |
Morral C, Batlle E |
| Citation(s) |
32396863 |
| Submission date |
Feb 20, 2020 |
| Last update date |
Jun 04, 2020 |
| Contact name |
Antoni Berenguer-LLergo |
| E-mail(s) |
aberenguerl@tauli.cat
|
| Organization name |
Parc Taulí Research and Innovation Institute (I3PT)
|
| Department |
A8G2 Group - Rheumatology Service
|
| Street address |
Parc del Taulí, 1
|
| City |
Sabadell |
| State/province |
Barcelona |
| ZIP/Postal code |
08208 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE125232 |
A cancer stem cell hierarchy based on differential ribosomal RNA and protein synthesis capacities |
|
| Relations |
| BioProject |
PRJNA607725 |
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