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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Feb 07, 2009 |
| Title |
GENE EXPRESSION OF AN ANTI-INFLAMMATORY PENTAPEPTIDE ON CIA MURINE DEVELOPMENT |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Monocyte Locomotion Inhibitory Factor (MLIF), an amoebic peptide, has an anti-inflammatory role, delaying the arrival of mononuclear cells to inflammatory sites, down regulating adhesin molecules and chemokines.
We used microarrays to detail the global gene expression underlying anti-inflammatory effect of MILF in an inflammatory model. Collagen type II (CII) emulsified on complet Freund adjuvant, was injected on the tail of the base of DBA1J mice, 8 weeks older, and booster with CII emulsified in incomple Freund adjuvant three weeks later. MLIF was administrated intranasally weekly since one week before induction.
Keywords: comparison effect
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| Overall design |
Articular tissues of all mices were collected at the peak time of clinical severity (four weeks before booster), for RNA extraction and hybridization on Affymetrix microarrays. We induces CIA with chicken collagen type II, emulsified with Complet Adjuvant of Freund, and the controls were mice induced only with Complet Adjuvant of Freund with or without MLIF
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| Contributor(s) |
Velazquez JR, Godina-González S, Terán LM |
| Citation(s) |
20582714 |
| Submission date |
Feb 05, 2009 |
| Last update date |
Sep 04, 2021 |
| Contact name |
Juan Velazquez |
| E-mail(s) |
velazquez_juan@hotmail.com
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| Organization name |
Instituto Mexicano del Seguro Social
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| Street address |
Alameda 45
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| City |
Zacatecas |
| State/province |
Zacatecas |
| ZIP/Postal code |
98000 |
| Country |
Mexico |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| GSM367776 |
CIA mice with MLIF, biological rep2 |
| GSM367777 |
Adjuvant mice, biological rep1 |
| GSM367778 |
Adjuvant mice, biological rep2 |
| GSM367779 |
Adjuvant mice with MLIF, biological rep1 |
| GSM367780 |
Adjuvant mice with MLIF, biological rep2 |
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| Relations |
| BioProject |
PRJNA112179 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE14721_RAW.tar |
36.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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