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| Status |
Public on Jul 15, 2020 |
| Title |
Genome-wide maps of chromatin state in rat IUGR islets at 2 time points |
| Organism |
Rattus norvegicus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Intrauterine growth restriction (IUGR) increases the risk of developing type 2 diabetes in adulthood. A rat model of IUGR induced by bilateral uterine artery ligation at day 18 of gestation, which reduces the blood supply and critical substrates to the fetus, was used to assess the alterations of genome-wide histone modifications in IUGR islets. At 2 and 10 weeks of age, pancreatic islets were isolated and chromatins were extracted for ChIP-Seq study. Chromatin state of H3K4me3, H3K27me3, and H3K27Ac modifications was compared in the study.
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| Overall design |
Examination of 3 different histone modifications in 2 experimental conditions (IUGR and Control) and 2 time points (2 and 10 weeks of age).
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| Contributor(s) |
Lien YC, Simmons RA, Wang PZ, Lu XM |
| Citation(s) |
32527043 |
| Submission date |
Apr 02, 2020 |
| Last update date |
Jul 15, 2020 |
| Contact name |
Paul Zhiping Wang |
| E-mail(s) |
upenn.bic@gmail.com
|
| Phone |
2155733117
|
| Organization name |
Bioinformatics Core, IBI, UPen
|
| Street address |
3440 Market St
|
| City |
Philadelphia |
| State/province |
pa |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
| GPL14844 |
Illumina HiSeq 2000 (Rattus norvegicus) |
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| Samples (61)
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| Relations |
| BioProject |
PRJNA622773 |
| SRA |
SRP255025 |
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