Metabolic reprogramming enforces Treg cell functional specialization in tumors by coordinating fatty acid biosynthesis and inhibitory receptor signaling pathways. These findings point to new avenues to selectively targeting intratumoral Treg cells for cancer therapy.
Overall design
In total 25 samples were analyzed: TIL Treg cells (WT, n = 7;Scap-KO, n = 3;Fasn-KO, n = 3;PD-1high WT Treg cells, n=4; PD-1low from WT Treg cells, n=4), WT Lymph node Treg from mice with no tumors (n=4).
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