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| Status |
Public on Oct 28, 2020 |
| Title |
Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
YAP and TAZ are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and cancer pathogenesis. Genetic deletion of YAP/TAZ has revealed their critical importance for embryonic development of the heart, vasculature and gastrointestinal mesenchyme. The aim of this study was to determine the functional role of YAP/TAZ in adult smooth muscle cell in vivo.
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| Overall design |
Distal colon and urinary bladder from 3 controls (Myh11CreERT2-negative-Yap1/Wwtr1 floxed) and 3 knockout (Myh11CreERT2-positive-Yap1/Wwtr1 floxed) were isolated and snap frozen in liquid nitrogen 7 days after the first (out of 5) tamoxifen injections
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| Contributor(s) |
Albinsson S |
| Citation(s) |
32992050 |
| Submission date |
May 14, 2020 |
| Last update date |
Oct 28, 2020 |
| Contact name |
Sebastian Albinsson |
| E-mail(s) |
sebastian.albinsson@med.lu.se
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| Organization name |
Lund University
|
| Street address |
BMC D12
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| City |
Lund |
| ZIP/Postal code |
22184 |
| Country |
Sweden |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA632892 |
| SRA |
SRP261665 |
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