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| Status |
Public on Dec 27, 2021 |
| Title |
RNA-seq data of nasopharyngeal carcinoma (NPC) cell and GO-PEG_erlotinib treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
graphene oxide (GO) is found to be a promising novel anti-cancer drug carrier. Erlotinib, a tyrosine kinase inhibitor (TKI) acting on the epidermal growth factor receptor (EGFR), has been proved for locally advanced or metastatic non-small cell lung cancer (NSCLC) and in combination with gemcitabine for locally advanced or metastatic pancreatic cancer in 2004, but its study in nasopharyngeal carcinoma (NPC) is still limited. We designed functionalized GO, polyethylene glycol-coated GO (GO-PEG), as drug carriers, which was loaded with erlotinib and showed promising anticancer effect on NPC cells. Our results showed that GO-PEG-erlotinib effectively suppressed NPC cell proliferation, migration, and invasion, likely by several mechanisms. GO-PEG-erlotinib may be the potential therapeutic agents for treating NPC in the future.
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| Overall design |
Total RNA from NPC cells treated with or without GO-PEG_erlotinib for 72 hours at 37°C was extracted with RNeasy Mini Kit (Qiagen, Germany) according to the manufacturer's protocol. RNA was subjected to RNA-Seq analysis on BGISEQ-500 system by Tri-I Biotech, Inc.
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| Web link |
http://DOI: 10.2147/IJN.S265437
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| |
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| Contributor(s) |
Lan M, Hsu Y, Lan M, Lu Y, Chen J |
| Citation(s) |
33116488 |
| Submission date |
May 26, 2020 |
| Last update date |
Dec 29, 2021 |
| Contact name |
MingYing Lan |
| E-mail(s) |
mingyinglan@gmail.com
|
| Organization name |
Taipei Veterans General Hospital, Taipei, Taiwan
|
| Department |
Department of Otolaryngology-Head and Neck Surgery
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| Street address |
No.201, Sec. 2, Shipai Rd., Beitou District
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| City |
Taipei |
| ZIP/Postal code |
11217 |
| Country |
Taiwan |
| |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA635104 |
| SRA |
SRP264795 |
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