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| Status |
Public on Sep 15, 2020 |
| Title |
RNA-seq of ATF-3 overexpressing and Neomycin control melanoma cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The present study demonstrates that ATF-3 plays a tumor suppressing function in melanoma. Overexpression of ATF-3 in metastatic melanoma cell lines significantly inhibited their growth, migration and invasion in vitro as well as inhibited tumor growth in human melanoma xenograft mouse model in vivo.
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| Overall design |
We performed RNA-seq of the melanoma cell lines A2058 and C8161 overexpressing ATF-3 by retroviral transduction and their corresponding neomycin controls.
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| Contributor(s) |
Lee CA, Frank NY |
| Citation(s) |
33299127 |
| Submission date |
Jun 15, 2020 |
| Last update date |
Dec 15, 2020 |
| Contact name |
Natasha Frank |
| Organization name |
Brigham and Women's Hospital
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| Department |
Medicine
|
| Lab |
Natasha Frank
|
| Street address |
77 Avenue Louis Pasteur
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA639461 |
| SRA |
SRP267326 |
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