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| Status |
Public on Aug 21, 2020 |
| Title |
Glioma cells response Interleukin-33 (IL-33) [microarray] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Determination of the molecular mechanism of IL33 on glioma cells
Since IL-33 is known to associate with chromatin and regulate transcriptional activity and that nuclear expression of IL-33 increases glioma progression, we determined Nuclear IL-33 regulates the expression and secretion of inflammatory cytokines in glioma cells. Using these parameters 340 genes were induced by the ectopic expression of IL-33 and an additional 377 genes were downregulated. Gene ontology terms over-represented in the genes induced by IL-33 include three major clusters that associate with cytokine activity and inflammation
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| Overall design |
We performed global gene expression analysis on 3 independent IL-33-ectopically-expressing glioma cell clones as compared to control (empty vector) cells.
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| Contributor(s) |
Robbins SM, Senger DL, DeBoeck A, Ahn B |
| Citation(s) |
33020472 |
| Submission date |
Jun 29, 2020 |
| Last update date |
Oct 27, 2020 |
| Contact name |
Stephen M Robbins |
| E-mail(s) |
srobbins@ucalgary.ca
|
| Phone |
(403) 220-4304
|
| Organization name |
University of Calgary
|
| Department |
Oncology
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| Lab |
HMRB 357
|
| Street address |
3330 Hospital Drive N.W.
|
| City |
Calgary |
| State/province |
Alberta |
| ZIP/Postal code |
T2N 4N1 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE153489 |
Cerebral immune cells in the Interleukin-33 (IL-33) driven tumor microenvironment |
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| Relations |
| BioProject |
PRJNA642838 |
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