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| Status |
Public on Aug 09, 2020 |
| Title |
Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity |
| Organisms |
Macaca mulatta; Papio anubis; Pan troglodytes; Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report the whole genome transcriptomic responses of ape species (human, common chimpanzee) and AAMs (rhesus macaque and olive baboon) to bacterial and viral stimulation. We find stark differences in the responsiveness of these groups, with apes mounting a markedly stronger early transcriptional response to both viral and bacterial stimulation, altering the transcription of ∼40% more genes than AAMs. Additionally, we find that genes involved in the regulation of inflammatory and interferon responses show the most divergent early transcriptional responses across primates and that this divergence is attenuated over time. Finally, we find that relative to AAMs, apes engage a much less specific immune response to different classes of pathogens during the early hours of infection, upregulating genes typical of anti-viral and anti-bacterial responses regardless of the nature of the stimulus
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| Overall design |
Whole blood stimulation of two stimulants that mimic bacterial and viral infections of whole blood obtained from 4 primate species, human, chimp, macaque and baboon.
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| Contributor(s) |
Fahmy Hawash MB, Sanz-Remón J, Grenier J, Kohn J, Yotova V, Johnson Z, Lanford RE, Brinkworth JF, Barreiro LB |
| Citation(s) |
33771921 |
| Submission date |
Aug 08, 2020 |
| Last update date |
Apr 20, 2021 |
| Contact name |
Luis B Barreiro |
| E-mail(s) |
lbarreiro@uchicago.edu
|
| Organization name |
Chicago University
|
| Department |
Genetic Medicine
|
| Lab |
Barreiro Lab
|
| Street address |
900 East 57th Street
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
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| Platforms (4)
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| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL14954 |
Illumina HiSeq 2000 (Macaca mulatta) |
| GPL16809 |
Illumina HiSeq 2000 (Pan troglodytes) |
| GPL18808 |
Illumina HiSeq 2000 (Papio anubis) |
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| Samples (151)
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| Relations |
| BioProject |
PRJNA656189 |
| SRA |
SRP276959 |
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