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| Status |
Public on Sep 30, 2020 |
| Title |
Targeting 14-3-3ζ overcomes resistance to EGFR-TKIs in lung adenocarcinoma via BMP2/Smad/ID1 signaling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
14-3-3ζ has been found to promote the proliferation, metastasis and chemoresistance of cancer cells in several cancers including lung adenocarcinoma; however, its significance in epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance remains unknown. Our work uncovers a hitherto unappreciated role of 14-3-3ζ in EGFR-TKI resistance.
We determined global gene expression profiling in EGFR-TKI-resistant H1975 cells using microarray analysis.
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| |
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| Overall design |
EGFR-TKI-resistant H1975 cells were infected with a lentivirus expressing either scrambled shRNA or 14-3-3ζ-shRNA
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| |
|
| Contributor(s) |
Lu H, Cai L |
| Citation(s) |
33123465 |
| Submission date |
Aug 18, 2020 |
| Last update date |
Nov 02, 2020 |
| Contact name |
Hailing Lu |
| E-mail(s) |
luhailing2004@hotmail.com
|
| Phone |
86-13836120825
|
| Organization name |
Harbin Medical University Cancer Hospital
|
| Street address |
150 Haping Road
|
| City |
Harbin |
| ZIP/Postal code |
150040 |
| Country |
China |
| |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
|
| Samples (6)
|
| GSM4731463 |
scrambled_shRNA_H1975 cells, biological rep1 |
| GSM4731464 |
scrambled_shRNA_H1975 cells, biological rep2 |
| GSM4731465 |
scrambled_shRNA_H1975 cells, biological rep3 |
| GSM4731466 |
14-3-3-zeta_shRNA_H1975 cells, biological rep1 |
| GSM4731467 |
14-3-3-zeta_shRNA_H1975 cells, biological rep2 |
| GSM4731468 |
14-3-3-zeta_shRNA_H1975 cells, biological rep3 |
|
| Relations |
| BioProject |
PRJNA657881 |
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