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| Status |
Public on Aug 22, 2022 |
| Title |
Gene expression analysis in mice with knockout of Xbp1 in intestinal epithelial cells during graft-versus-host disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We analyzed gene expression in mice with a deletion of Xbp1 in their intestinal epithelial cells and their littermates during graft-versus-host disease. Xbp1 is a central transcription factor that mediates the unfolded protein response following endoplasmic reticulum stress.
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| Overall design |
Villin-Cre Xbp1 fl/fl mice (Knock-out, KO) and Xbp1 fl/fl (wildtype, WT) littermates underwent allogeneic hematopoietic cell transplantation in a major-mismatch-model with total body irradiation as a conditioning treatment. On day 14 after transplantation, RNA from the small intestine of recipient mice was isolated and Affymetrix microarrays were performed.
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| Contributor(s) |
Apostolova P, Haring E, Andrieux G, Boerries M |
| Citation(s) |
34407601 |
| Submission date |
Aug 19, 2020 |
| Last update date |
Aug 25, 2022 |
| Contact name |
Geoffroy Andrieux |
| Organization name |
University clinics Freiburg
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| Street address |
Breisacherstr 153
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| City |
Freiburg |
| ZIP/Postal code |
79110 |
| Country |
Germany |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA658067 |
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