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Series GSE157547 Query DataSets for GSE157547
Status Public on Nov 18, 2020
Title Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Black men die more often of prostate cancer (PC) yet, interestingly, may derive greater survival benefits from immunotherapy. Since no signatures of immune-responsiveness exist for PC, we explored race-based immune-profiles to identify vulnerabilities.
Black men have increases in plasma cell infiltrate and associated augmented NK cell and IgG activity. These findings are associated with improved survival and nominate plasma cells as drivers of PC immune-responsiveness.
 
Overall design This validation cohort was comprised of a large retrospective cohort with whole transcriptomic data (DVA; n=538). Race was patient-identified in this cohort (236 White and 302 Black). This group was comprised of genome-wide expression profiles from formalin-fixed paraffin-embedded prostate tumors from radical prostatectomy between 1989 and 2016.
 
Contributor(s) Weiner AB, Vidotto T, Liu Y, Mendes AA, Salles DC, Faisal FA, Murali S, McFarlane M, Imada EL, Zhao X, Li Z, Elai E, Marchionni L, Chinnaiyan AM, Freedland SJ, Spratt DE, Wu JD, Lotan TL, Edward EM
Citation(s) 33568675
Submission date Sep 05, 2020
Last update date Feb 17, 2021
Contact name Elai Davicioni
E-mail(s) elai@decipherbio.com
Organization name Decipher Biosciences, Inc.
Street address 1152 Mainland St, Suite 430
City Vancouver
State/province BC
ZIP/Postal code V6B 4X2
Country Canada
 
Platforms (1)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (538)
GSM4769787 PCA.1: prostate_cancer_primary_1
GSM4769788 PCA.2: prostate_cancer_primary_2
GSM4769789 PCA.3: prostate_cancer_primary_3
This SubSeries is part of SuperSeries:
GSE157548 Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes
Relations
BioProject PRJNA661756

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE157547_RAW.tar 10.4 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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