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| Status |
Public on Sep 18, 2020 |
| Title |
Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on temporomandibular joint osteoarthritis in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Temporomandibular joint osteoarthritis (TMJ-OA), a subtype of temporomandibular joint dysfunction (TMD), is characterized by progressive cartilage degradation, subchondral bone erosion, and chronic pain. Although there has been extensive research on TMJ-OA, its etiology remains unknown. Age, hormonal factors, and excessive mechanical stress on the TMJ are proposed risk factors for TMJ-OA.
Using microarrays, we discovered two disease susceptibility genes that have been suggested to be involved in the pathogenic mechanism of TMJ-OA.
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| Overall design |
For experimental groups, orchiectomy (ORX) or ovariectomy (OVX) was performed on sexually mature 8-week old mice. To apply excessive mechanical stress (MS) on mandibular condyles, a metal plate was attached to the posterior surface of the maxillary incisors. Male mice were divided into control, ORX, MS, and ORX+MS group, while female mice were divided into control, OVX, MS, and OVX+MS groups. Microarray analysis was conducted using a Clariom S Assay (Mouse, Thermo Fisher Scientific) for comprehensive analysis of related genes.
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| Contributor(s) |
Ootake T, Ishii T, Sueishi K, Watanabe A, Ishizuka Y, Amano K, Nagao M, Nishimura K, Nishii Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 17, 2020 |
| Last update date |
Sep 20, 2020 |
| Contact name |
Tomohisa Ootake |
| E-mail(s) |
ootaketomohisa@tdc.ac.jp
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| Organization name |
Tokyo Dental College
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| Lab |
Tomohisa Ootake
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| Street address |
2-9-18 Kanda-Misakicho
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| City |
Chiyoda-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
101-0061 |
| Country |
Japan |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA664022 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE158106_RAW.tar |
10.2 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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