|
| Status |
Public on Sep 19, 2020 |
| Title |
Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [scRNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
scRNA-sequencing of human xenotransplanted microglia isogenic for TREM2 after exposure to amyloid pathology
|
| |
|
| Overall design |
Single-cell comparison of WT and KO TREM2 microglia isolated from 6 month old WT and 5X-MITRG mice
|
| |
|
| Contributor(s) |
McQuade A, Hasselmann J |
| Citation(s) |
33097708 |
| Submission date |
Sep 18, 2020 |
| Last update date |
Nov 05, 2020 |
| Contact name |
Mathew Blurton-Jones |
| E-mail(s) |
mblurton@uci.edu
|
| Organization name |
University of California, Irvine
|
| Department |
Neurobiology and Behavior
|
| Street address |
845 Health Sciences Road, Room 3200
|
| City |
Irvine |
| State/province |
CA |
| ZIP/Postal code |
92617 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (4)
|
|
| This SubSeries is part of SuperSeries: |
| GSE158470 |
Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo |
|
| Relations |
| BioProject |
PRJNA664397 |
| SRA |
SRP283885 |
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