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Series GSE159108 Query DataSets for GSE159108
Status Public on Feb 24, 2021
Title Generation and characterization of human iPSC-derived microglia-like cells for the use in drug discovery
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary For the development of human cellular models of microglial that allow for exploring disease underlying mechanisms and testing potential therapeutic compounds on a larger scale we generated microglia-like cells from human induced pluripotent stem cells (iPSC) and performed subsequent phenotypic and functional testing and validation by using bulk RNASeq.
 
Overall design We compared the differentiation of myeloid progenitors for additional 14 days to microglia like-cells and compared these monocultures to already published co-cultures.
 
Contributor(s) Schmucki R, Koechl F, Reich M, Paris I, Gutbier S, Dahm N, Schweitzer C, Reinhardt D, Cowley SA, Ebeling M, Zhang D, Patsch C, Britschgi M
Citation(s) 33613545
BioProject PRJNA667596
Submission date Oct 06, 2020
Last update date Feb 24, 2021
Contact name Roland Schmucki
E-mail(s) roland.schmucki@roche.com
Organization name F. Hoffmann - La Roche AG
Street address Grenzacherstrase
City Basel
ZIP/Postal code 4058
Country Switzerland
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (20)
GSM4819637 RNASeq of homo sapiens: macrophage precursor (01_Mo_WT_Ctrl)
GSM4819638 RNASeq of homo sapiens: macrophage precursor (02_Mo_WT_Ctrl)
GSM4819639 RNASeq of homo sapiens: macrophage precursor (03_Mo_WT_Ctrl)
Relations
SRA SRP286488

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE159108_counts.gct.gz 928.4 Kb (ftp)(http) GCT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
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