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| Status |
Public on Jan 29, 2021 |
| Title |
Feeding differentially regulates clocks and rhythmicity of peripheral tissues through the liver-clock |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The mammalian circadian system consists of a central clock in the brain that synchronizes clocks in peripheral tissues. While the hierarchy between the central and peripheral clocks is well established, peripheral clocks are largely viewed as a group and little is known regarding their specificity and functional organization. We employed feeding paradigms in conjunction with liver-specific clock-deficient murine model to map disparities and potential interactions between peripheral clocks. We found that peripheral clocks largely differ in their response to feeding-time. In view of its prominent role in nutrient processing, we hypothesized that the liver-clock instigate the response of peripheral clocks to feeding. Although the liver-clock did not affect the rhythmicity of clocks in other peripheral tissues, it strongly modulated their transcriptional rhythmicity upon daytime feeding. Overall, our findings suggest a role for the liver-clock in buffering feeding-related signals that affect rhythmicity of other peripheral tissues upon nutrient challenge, irrespective of their clocks.
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| Overall design |
Mice of either Alb-Cre+ (control) or Bmal1 fl/fl Alb-Cre+ (aka BLKO), where fed either Ad Libitum (AL) or only during the light-phase (Daytime-feeding, DF)
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| Contributor(s) |
Manella G, Asher G, Golik M, Sabbath E |
| Citation(s) |
34059820 |
| Submission date |
Oct 06, 2020 |
| Last update date |
Jun 18, 2021 |
| Contact name |
Gal Manella |
| Organization name |
Weizmann Institute of Science
|
| Street address |
234 Herzel St.
|
| City |
Rehovot |
| State/province |
Israel |
| ZIP/Postal code |
7610001 |
| Country |
Israel |
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| Platforms (1) |
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| Samples (288)
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| Relations |
| BioProject |
PRJNA667743 |
| SRA |
SRP286568 |
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