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| Status |
Public on Oct 20, 2020 |
| Title |
FAM83H-AS1 is a non-coding oncogenic driver and therapeutic target of lung adenocarcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our study suggested that FAM83H-AS1 was a potential oncogenic driver due to chromosome 8q24 amplification in lung adenocarcinoma. To investigate the molecular mechanism of FAM83H-AS1, we performed high-thoughput RNA sequencing (RNA-Seq) assays after the silence of FAM83H-AS1 in A549 cell lines.
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| Overall design |
In human lung adenocarcinoma A549 cells, we downregulated the expression of FAM83H-AS1 utilizing small interference RNA (siRNA) and used scrumble as negative control. Then we used RNA-Seq to reveal the change of mRNA profiles after the silence of FAM83H-AS1.
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| Contributor(s) |
Wang S, Ma Z, Xia W, Qiu M, Yin R |
| Citation(s) |
33634993 |
| Submission date |
Oct 19, 2020 |
| Last update date |
Feb 27, 2021 |
| Contact name |
Rong Yin |
| E-mail(s) |
rong_yin@njmu.edu.cn
|
| Organization name |
Nanjing Medical University Affiliated Jiangsu Cancer Hospital
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| Department |
Thoracic Surgery
|
| Street address |
Baiziting 42
|
| City |
Nanjing |
| ZIP/Postal code |
210009 |
| Country |
China |
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| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA669700 |
| SRA |
SRP287504 |
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