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| Status |
Public on Dec 19, 2020 |
| Title |
Different forms of KLF5 transcriptionally regulate distinct sets of genes in prostate cancer cells [ChIP-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
To identify which genes are directly regulated by KLF5 and its acetylation, we performed ChIP-Seq and bioinformatics analyses in KLF5-null prostate cancer cells expressing KLF5, KLF5KR, and KLF5KQ.
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| Overall design |
ChIP-Seq analyses were performed using KLF5 knockout DU 145 and PC-3 cells that ectopically expressed empty vector (EV), wildtype KLF5 (KLF5); acetylation deficient mutant KLF5K369R (KR), and acetylation mimicking mutant KLF5K369Q (KQ).
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| Contributor(s) |
Dong J, Zhang B, Li Y, Wu Q, Barwick B |
| Citation(s) |
33731701 |
| Submission date |
Nov 22, 2020 |
| Last update date |
Mar 20, 2021 |
| Contact name |
Jin-Tang Dong |
| E-mail(s) |
dongjt@sustech.edu.cn
|
| Organization name |
Southern University of Science and Technology
|
| Department |
Human Cell Biology and Genetics
|
| Street address |
1088 Xueyuan Blvd
|
| City |
Shenzhen |
| State/province |
Guangdong |
| ZIP/Postal code |
518055 |
| Country |
China |
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| Platforms (1) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE161951 |
Different forms of KLF5 regulate distinct sets of genes in prostate cancer cells |
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| Relations |
| BioProject |
PRJNA680029 |
| SRA |
SRP293678 |
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