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| Status |
Public on Jan 06, 2021 |
| Title |
Integrative analysis of intrinsic and adaptive resistance to KRASG12C inhibitors in lung adenocarcinoma models |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
KRASG12C inhibitors have been widely reported and studied in recent years. Some of the inhibitors, such as AMG510 and ARS1620, have been reported in clinical studies to be effective in treating patients with non-small cell lung cancer (NSCLC). However, the rapid development of drug resistance in tumor cells will delay the clinical application of these drugs. Therefore, how to block the resistance to these inhibitors in tumor cells with KRASG12C mutations is crucial. We report the alteration in transcriptomics of NSCLC cell line H358 after long-term ARS1620 treatment to explore the mechanism of H358 resistance.
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| Overall design |
mRNA profiles of H358-P (H358 cell treated with ARS-1620 for 0 hour), ARS-24H (H358 cell treated with ARS-1620 for 24 hours), ARS-48H (H358 cell treated with ARS-1620 for 48 hours), and H358-R (H358 cell treated with ARS-1620 for long period until it is resistant to ARS1620).
mRNA profiles of H358_P (H358 cell treated with ARS-1620 for 0 hour), H358_ARS (H358 cell treated with ARS-1620 for 24 hours), H358_M1 (H358 cell treated with ARS-1620 for 24 hours with M1-type macrophage conditional medium), H358_M2 (H358 cell treated with ARS-1620 for 24 hours with M1-type macrophage conditional medium)
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| Contributor(s) |
Mangze H, En W, Ying L |
| Citation(s) |
34858498 |
| Submission date |
Jan 05, 2021 |
| Last update date |
Jan 23, 2023 |
| Contact name |
mangze hu |
| E-mail(s) |
humangze@gmail.com
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| Organization name |
nantong university
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| Lab |
zhou, xiaorong
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| Street address |
qixiu street 19
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| City |
nantong |
| ZIP/Postal code |
230000 |
| Country |
China |
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| Platforms (1) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA689906 |
| SRA |
SRP300574 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE164326_RAW.tar |
2.7 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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