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| Status |
Public on Feb 25, 2024 |
| Title |
Circulating neutrophil transcriptomics in HBV-ACLF patients. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The transcriptomic profiles of circulating neutrophils were compared between patients with ACLF (N=10), patients with CLC (N=10) and HC (N=10). Compared with CLC-neutrophils, the expression of 1022 genes were found to be upregulated in ACLF-neutrophils, and 1101 genes were downregulated. And compared to HC, the expression of 726 genes were up-regulated in ACLF-neutrophils, and 711 genes were down-regulated. The pathway analysis identified mutiple pathways enriched or down-regulated in ACLF-neutrophils when comparing with neutrophils from CLC or HC groups.
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| Overall design |
The transcriptomic profiles of circulating neutrophils were compared between patients with ACLF (N=10), patients with CLC (N=10) and HC (N=10).
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| Contributor(s) |
Wu W, Sun S, Zhao R, Sheng J, Chen Z, Shi Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 18, 2021 |
| Last update date |
Feb 25, 2024 |
| Contact name |
Shanshan Sun |
| E-mail(s) |
11718142@zju.edu.cn
|
| Phone |
057187236491
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| Organization name |
The First Affiliated Hospital, Zhejiang University School of Medicine
|
| Department |
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
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| Street address |
Qingchun Road, No 79
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| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
310003 |
| Country |
China |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA692986 |
| SRA |
SRP302196 |
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