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| Status |
Public on Feb 09, 2021 |
| Title |
CDK9 inhibitor induces the apoptosis of acute lymphocytic leukemia by inhibiting c-Myc-mediated glycolytic metabolism |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose:the inhibitory effect of CDK9i on the energy metabolism of B-ALL cells remains unclear. To address this question, we collected SNS-032- and DMSO-treated cells for RNA sequencing
Methods:REH cells were seeded at a density of 1× 106 cells/ml and treated with 200nm SNS_032 or DMSO for 24h.
Results:CDK9i perturbs the glycolytic metabolism of B-ALL cells in vitro.
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| |
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| Overall design |
REH total mRNA profiles treated with 200nm SNS_032 or DMSO for 24h.
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| |
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| Contributor(s) |
Huang W, Abudureheman T, Guo S, Yin G, Duan C |
| Citation(s) |
33748130 |
| Submission date |
Feb 08, 2021 |
| Last update date |
Mar 23, 2021 |
| Contact name |
xia jing |
| E-mail(s) |
xiajing@scmc.com.cn
|
| Organization name |
Shanghai Children’s Medical Center
|
| Street address |
1678 Dongfang Road
|
| City |
Shanghai |
| ZIP/Postal code |
200127 |
| Country |
China |
| |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA700568 |
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