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| Status |
Public on Aug 16, 2021 |
| Title |
Genome-wide profiling of histone H1 variants in T47D-MTVL cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Human somatic cells may contain up to seven members of the histone H1 family contributing to chromatin compaction and regulation of nuclear processes, apparently with certain subtype specificities. Previous studies in T47D breast cancer cells determined that H1 variants are distributed in a variant-specific manner throughout the genome, although only H1.2 and H1X endogenous variants were mapped. Now, we performed ChIP-seq of five endogenous H1 variants (H1.0, H1.2, H1.4, H1.5, H1X) in T47D cells.
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| Overall design |
Genomic distribution of H1.0, H1.2, H1.4, H1.5, and H1X linker histones in T4LD-MTVL cells (ChIP-seq)
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| Contributor(s) |
Jordan A, Serna N, Salinas M |
| Citation(s) |
35380694, 38261975, 38530350 |
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Núria Serna-Pujol, Mónica Salinas-Pena, Francesca Mugianesi, François Le Dily, Marc A. Marti-Renom, and Albert Jordan. Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion. bioRxiv 2021.02.12.429879. doi:10.1101/2021.02.12.429879
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| Submission date |
Feb 11, 2021 |
| Last update date |
Apr 04, 2024 |
| Contact name |
Albert Jordan |
| E-mail(s) |
ajvbmc@ibmb.csic.es
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| Organization name |
IBMB-CSIC
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| Department |
Molecular Genomics
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| Street address |
Baldiri Reixac 4
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| City |
Barcelona |
| ZIP/Postal code |
08028 |
| Country |
Spain |
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| Platforms (1) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA701478 |
| SRA |
SRP305934 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE166645_RAW.tar |
856.3 Mb |
(http)(custom) |
TAR (of WIG) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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