|
| Status |
Public on Nov 03, 2021 |
| Title |
Identification of JMJD1A and JMJD2B target genes in hypoxic colon carcinoma cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression.
This dataset includes expression data obtained from exposing colon carcinoma cells to hypoxia in combination with siRNA-mediated knockdown of the hypoxia-inducible histone demethylases JMJD1A and JMJD2B.
|
| |
|
| Overall design |
18 samples were analyzed. The log2-transformed normalized signal intensities were used for downstream pairwise comparisons (using Partek Genomic Suite):
SiControl-Normoxia>SiJMJD1A-Normoxia;
SiJMJD1A-Normoxia>SiControl-Normoxia;
SiControl-Normoxia>SiJMJD2B-Normoxia;
SiJMJD2B-Normoxia>SiControl-Normoxia;
SiControl-Hypoxia>SiControl-Normoxia;
SiControl-Normoxia>SiControl-Hypoxia;
SiControl-Hypoxia>SiJMJD1A-Hypoxia;
SiJMJD1A-Hypoxia>SiControl-Hypoxia;
SiControl-Hypoxia>SiJMJD2B-Hypoxia;
SiJMJD2B-Hypoxia>SiControl-Hypoxia.
|
| |
|
| Contributor(s) |
Qiu L, Krieg AJ |
| Citation(s) |
34766154 |
|
https://doi.org/10.1002/mco2.85
|
| Submission date |
Feb 17, 2021 |
| Last update date |
Nov 18, 2021 |
| Contact name |
Lei Qiu |
| E-mail(s) |
qiuleisophia@sina.com
|
| Phone |
18382097309
|
| Organization name |
sichuan university
|
| Department |
Department of General Surgery, Frontiers Science Center for Disease-related Molecular Network, and Cancer Center, West China Hospital
|
| Lab |
Research Laboratory of Cancer Epigenetics and Genomics
|
| Street address |
No. 17, Section 3, Renmin South Road
|
| City |
chengdu |
| State/province |
sichuan |
| ZIP/Postal code |
610041 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA702536 |
Less...
More...