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Series GSE167074 Query DataSets for GSE167074
Status Public on Feb 10, 2024
Title RNA sequencing of sputum cells from a phase IIa placebo controlled clinical trial of Risankizumb in severe asthma
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Interleukin (IL)-23 is implicated in T2 and T17-mediated airway inflammation, supporting a role in asthma. We undertook a Phase II, randomized, double-blind, placebo-controlled, 24-week, parallel-group, multicenter trial to assess the efficacy and safety of risankizumab, an IL23p19 monoclonal antibody, administered subcutaneously (90 mg 4 weekly) in adults with severe asthma. Sputum samples were collected at several timepoints: visit 1B (week -3), visit 2 (week 0 proir to treatment), visit 7 (week 20), visit 8 (week 24, end of treatment), visit 12 (week 40, end of observation). RNA sequencing of sputum cells.
 
Overall design Comparison of sputum cells from asthma patients treated with either placebo or Risankizumab.
 
Contributor(s) Cousins DJ
Citation(s) 34706172
Submission date Feb 19, 2021
Last update date Feb 10, 2024
Contact name David John Cousins
E-mail(s) dc282@leicester.ac.uk
Organization name University of Leicester
Department Respiratory Sciences
Lab Cousins lab
Street address NIHR BRC Respiratory, Glenfield Hospital
City Leicester
ZIP/Postal code LE3 9QP
Country United Kingdom
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (680)
GSM5092168 TMG059_6_S40_L007_R1_001.fastq.gz
GSM5092169 TMG059_9_S30_L008_R1_001.fastq.gz
GSM5092170 TMG059_14_S46_L008_R1_001.fastq.gz
Relations
BioProject PRJNA702919
SRA SRP307096

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE167074_RIS_GEOprocessed_data2_270321.txt.gz 55.6 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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