|
| Status |
Public on Nov 11, 2022 |
| Title |
A novel ERK substrate regulates wide varieries of IEGs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The ERK pathway induces cell proliferation in response to growth factor stimulation. Although ERK controls various transcription factors in the nucleus, gene regulation mechanisms underlying the rapid IEG inductions were not fully elucidated. Here we report that ERK phosphorylates an unique novel substrate. We found that ERK facilitates rapid transcription of IEGs through the phosphorylation of the substrate.
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| |
|
| Overall design |
mRNA expressions of EGF-treated or non-treated HEK293-WT and -4A cells
|
| |
|
| Contributor(s) |
Ohe S, Kubota Y, Takekawa M, Yamaguchi K, Furukawa Y, Hata Y, Oyama M |
| Citation(s) |
36463234 |
| Submission date |
Feb 22, 2021 |
| Last update date |
Jan 04, 2023 |
| Contact name |
Mutsuhiro Takekawa |
| Organization name |
The University of Tokyo
|
| Department |
Institute of Medical Science
|
| Lab |
Division of Cell Signaling and Molecular Medicine
|
| Street address |
4-6-1
|
| City |
Shirokanedai |
| State/province |
Minato-ku, Tokyo |
| ZIP/Postal code |
108-8639 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA703962 |
| SRA |
SRP307517 |
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