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| Status |
Public on Dec 31, 2021 |
| Title |
Expression data from vtiligo skin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Vitiligo is a skin disorder due to loss of melanocytes. There are depigmented lesions mixed with normally-pigmented non-lesions. Gene expression profiles have been different between lesional skin and non-lesional skin. Primary cilia have been involved in various cellular functions including cell survival.
We used microarrays to detail the programme of gene expression underlying melanocyte survival in vitiligo and identified distinct cilia-related genes involved in melanocyte apoptosis.
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| Overall design |
Lesional and non-lesional skin specimen sets were selected for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain up- or down-regulated gene profiles in lesional skin compared to those in non-lesional skin specimens. To that end, we biopsed lesional and non-lesional skin specimens from the same patient.
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| Contributor(s) |
Lee A |
| Citation missing |
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| Submission date |
Mar 05, 2021 |
| Last update date |
Jan 01, 2022 |
| Contact name |
Ai-Young Lee |
| E-mail(s) |
lay5604@naver.com
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| Phone |
82-10-2695-7240
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| Organization name |
Dongguk University School of Medicine
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| Department |
Dermatology
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| Street address |
Ilsandong-gu Siksa-dong Dongguk-ro 27
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| City |
Goyang-si |
| State/province |
Gyeonggi-do |
| ZIP/Postal code |
410-773 |
| Country |
South Korea |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA706910 |
