|
| Status |
Public on Mar 18, 2021 |
| Title |
Dysregulated gene expression in human osteoarthritis cartilage |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Osteoarthritis causes pain and functional disability for over 500 million people worldwide and characterized by progressive loss of cartilage from the articulating surfaces of diarthrodial joints. Although the etiology of the disease is unknown, it is widely accepted that these degenerative changes arise from an imbalance of synthetic and degradative pathways that control cartilage extracellular matrix metabolism. Genome-wide U133A Affymetrix oligonucleotide array set was used to comprehensively investigate the expression pattern in non-osteoarthritis (normal) and cartilage obtained from OA patients undergoing knee replacement surgery. This study was undertaken to better understand the molecular basis of the disease and to provide relevant insight into phenotypical alterations and mechanisms involved in OA pathogenesis.
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| |
|
| Overall design |
Analyzed 5 normal and 6 OA pool samples. Each pool has 5 individual RNA samples pooled for target preparation.
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| |
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| Contributor(s) |
Attur M, Abramson SB |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 17, 2021 |
| Last update date |
Mar 21, 2021 |
| Contact name |
MUKUNDAN ATTUR |
| E-mail(s) |
mukundan.attur@nyulangone.org
|
| Phone |
2125986578
|
| Organization name |
NYU GROSSMAN SCHOOL OF MEDICINE
|
| Department |
MEDICINE
|
| Lab |
RHEUMATOLOGY RESEARCH ALB
|
| Street address |
301E, 17TH STREET FL16, RM1609
|
| City |
NEW YORK |
| State/province |
NY |
| ZIP/Postal code |
10003 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (11)
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| Relations |
| BioProject |
PRJNA715169 |
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