|
| Status |
Public on Mar 30, 2021 |
| Title |
CD22 blockage restores age-related impairments of microglia surveillance capacity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report that antibody-mediated CD22 blockage leads to an altered transcriptomic signature profile which, by further evaluating the affected genes, resembles a homeostatic phenotype.
|
| |
|
| Overall design |
Assessment of RNA expression levels following antibody-mediated blockage of CD22 in human iPSC-derived macrophages.
|
| |
|
| Contributor(s) |
Schmucki R, Kueng E, Ebeling M, Gutbier S, Harde E |
| Citation(s) |
33613545, 34140954 |
| Submission date |
Mar 19, 2021 |
| Last update date |
Jul 01, 2021 |
| Contact name |
Roland Schmucki |
| E-mail(s) |
roland.schmucki@roche.com
|
| Organization name |
F. Hoffmann - La Roche AG
|
| Street address |
Grenzacherstrase
|
| City |
Basel |
| ZIP/Postal code |
4058 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA715777 |
| SRA |
SRP311390 |
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