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| Status |
Public on Nov 25, 2021 |
| Title |
Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Tissue factor pathway inhibitor (TFPI) is a prominent regulator of blood coagulation and an intriguing constituent of trophoblast cells situated at the maternal-fetal interface. The actions of TFPI extend beyond controlling hemostasis and directly affect trophoblast cell development. TFPI facilitates the differentiation of rat and human trophoblast stem cells into the invasive trophoblast/extravillous cell lineage and promotes intrauterine trophoblast invasion and trophoblast-guided uterine spiral artery remodeling at the maternal-fetal interface. Thus, TFPI is a conserved regulator of a fundamental event determining the efficacy of the hemochorial placenta.
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| Overall design |
Rat trophoblast stem cells were differentiated for eight days (Okae et al.) into extravillous trophoblast (EVT). On day eight of differentiation, cells were collected and RNA was isolated.
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| Contributor(s) |
Muto M, Iqbal K, Soares MJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 08, 2021 |
| Last update date |
Nov 25, 2021 |
| Contact name |
Khursheed Iqbal |
| E-mail(s) |
kiqbal@kumc.edu
|
| Phone |
913 588 5690
|
| Organization name |
University of Kansas Medical Center
|
| Department |
Pathology
|
| Street address |
3901 Rainbow Blvd
|
| City |
Kansas City |
| State/province |
Kansas |
| ZIP/Postal code |
66160 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL14844 |
Illumina HiSeq 2000 (Rattus norvegicus) |
|
| Samples (6)
|
| GSM5233434 |
Rat trophoblast stem cell [Sample_C1Stem] |
| GSM5233435 |
Rat trophoblast stem cell [Sample_C2Stem] |
| GSM5233436 |
Rat trophoblast stem cell [Sample_C3Stem] |
| GSM5233437 |
Differentiated Rat trophoblast stem cell [Sample_D8-1] |
| GSM5233438 |
Differentiated Rat trophoblast stem cell [Sample_D8-2] |
| GSM5233439 |
Differentiated Rat trophoblast stem cell [Sample_D8-3] |
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| This SubSeries is part of SuperSeries: |
| GSE171755 |
Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation |
|
| Relations |
| BioProject |
PRJNA721711 |
| SRA |
SRP314715 |
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