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| Status |
Public on Apr 28, 2024 |
| Title |
Non-coding RNA and mRNA expression profile in multi-drug resistance of colorectal cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Background: Non-coding RNAs have been proved to play an essential role in the development and progression of various cancers. However, the functions and mechanisms of non-coding RNA and mRNA in multi-drug resistance of colorectal cancer have not been fully elucidated.Methods: We performed RNA-sequencing to screen differentially expressed non-coding RNA and mRNA in CRC chemo-resistant and chemo-sensitive cell lines. Results: The results showed that 1779 mRNAs, 64 miRNAs, 11 circRNAs and 295 lncRNAs were common differentially expressed in two chemo-resistant cell lines.Conclusions:The results of the study may provide new theories and therapeutic targets for multi-drug resistance in colorectal cancer.
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| Overall design |
To detect the non-coding RNA and mRNA expression profiles in colorectal cancer chemo-resistant and chemo-sensitive cell lines.
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| Contributor(s) |
Wu Q, Yao F, Wang Q, Xiang X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 29, 2021 |
| Last update date |
Apr 28, 2024 |
| Contact name |
Qingming Wu |
| Organization name |
wuhan university of science and technology
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| Street address |
huangjiahu east
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| City |
wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430065 |
| Country |
China |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA726252 |
| SRA |
SRP317902 |
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