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| Status |
Public on Jun 11, 2021 |
| Title |
Impaired antigen-specific memory B cell and plasma cell responses including lack of specific IgG upon SARS-CoV-2 BNT162b2 vaccination among Kidney Transplant and Dialysis patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
Single cell transcriptome, cell-surface proterin, TCR and BCR sequencing of FACS-sorted activated T and B cells of the peripheral blood of patients vaccinated against COVID19 after kidney transplant transplantation
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| Overall design |
Sequencing of RNA, TCR and BCR was performed from FACS-sorted activated T cells (CD38+ HLA-DR+), memory B cells (CD38low CD27+) and plasmabolasts (CD38high CD27high) from the peripheral blood of four patients vaccinated against COVID19 after kidney transplantation, using the 10X Genomics platform with the Single Cell 5’ Library & Gel Bead Kit
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| Contributor(s) |
Schrezenmeier E, Ferreira-Gomes M, Guerra GM, Lehmann K, Heinrich F, Durek P, Mashreghi M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 09, 2021 |
| Last update date |
Jun 13, 2021 |
| Contact name |
Pawel Durek |
| E-mail(s) |
pawel.durek@drfz.de
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| Organization name |
Deutsches Rheuma-Forschungszentrum
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| Street address |
Charitéplatz 1
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| City |
Berlin |
| ZIP/Postal code |
10117 |
| Country |
Germany |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA736300 |
| SRA |
SRP323339 |
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