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Series GSE17757 Query DataSets for GSE17757
Status Public on Jun 10, 2010
Title Gene expression data from primate postnatal brain in prefrontal cortex: time course
Platform organism Homo sapiens
Sample organisms Macaca mulatta; Homo sapiens
Experiment type Expression profiling by array
Summary Gene expression changes determine functional differentiation during development and are associated with functional decline during aging. While developmental changes are tightly regulated, regulation of aging changes is not well established. To assess the regulatory basis of age-related changes and investigate the mechanism of regulatory transition between development and aging, we measured mRNA and microRNA expression patterns in brains (superior frontal gyrus) of humans and rhesus macaques over the entire species’ lifespan. We find that in both species, developmental and aging changes overlap in the course of lifetime with many changes found at the late age initiating in early childhood.
 
Overall design Human post-mortem brain samples from the superior frontal gyrus region of the prefrontal cortex were collected. The age ranges of the indibiual in human covered its whole life span fom newborn to death. RNA extracted from the dissected tissue was hybridized to Affymetrix® Human Gene 1.0 ST arrays.

Rhesus macaque post-mortem brain samples from the superior frontal gyrus region of the prefrontal cortex were collected. The age ranges of the indibiual in rhesus macaque covered the whole life span fom newborn to death. RNA extracted from the dissected tissue was hybridized to Affymetrix® Human Gene 1.0 ST arrays.
 
Contributor(s) Somel M, Guo S, Fu N, Yan Z, Khaitovich P
Citation(s) 20647238, 28724976
Submission date Aug 21, 2009
Last update date Jun 05, 2019
Contact name Song Guo
Organization name PICB
Street address 320 Yue Yang Road
City shanghai
ZIP/Postal code 200031
Country China
 
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (51)
GSM443475 Affymetrix: Human-superior frontal gyrus-2 day old
GSM443476 Affymetrix: Human-superior frontal gyrus-4 days old
GSM443477 Affymetrix: Human-superior frontal gyrus-34 days old
This SubSeries is part of SuperSeries:
GSE18069 Gene and miRNA expression data from primate postnatal brain in prefrontal cortex: time course
Relations
BioProject PRJNA123531

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17757_HuGene1.0_human_probe.xls.gz 1.2 Mb (ftp)(http) XLS
GSE17757_HuGene1.0_maca_probe.xls.gz 1.2 Mb (ftp)(http) XLS
GSE17757_RAW.tar 162.8 Mb (http)(custom) TAR (of CEL)
GSE17757_guosong_HuGene1.0_human_probe.txt.gz 3.3 Mb (ftp)(http) TXT
GSE17757_guosong_HuGene1.0_maca_probe.txt.gz 1.3 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record
Processed data provided as supplementary file
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