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| Status |
Public on Jun 05, 2023 |
| Title |
Profiling of a series of triple positive (CD10+BCL6+MUM1+) diffuse large B-cell lymphoma cases |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by array
Genome variation profiling by SNP array
|
| Summary |
Gene expression profiling (GEP) divides DLBCL according to the cell of origin into GCB, ABC and unclassifiable, exhibiting different mutational profiles. The Hans algorithm, a surrogate of GEP, classifies cases expressing CD10, BCL6 and MUM1 as GCB but it is not clear whether all these cases correspond to GCB-type. Accordingly, LBCL with IRF4 rearrangement usually expresses GCB phenotype (CD10+, BCL6+) together with strong MUM1/IRF4.
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| Overall design |
The aim of this study was to characterize the molecular heterogeneity of DLBCL triple positive (CD10+ BCL6+MUM1+) in adults. CN alterations were examined in 9 out of 13 cases with available material and IRF4 rearrangement and/or IRF4 mutations using OncoScan platform
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| Contributor(s) |
Castrejon-de-Anta N, Frauenfeld L, Balagué O, Quintanilla-Martinez L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 17, 2021 |
| Last update date |
Jun 07, 2023 |
| Contact name |
Joan Enric Ramiz-Zaldivar |
| E-mail(s) |
ramis@clinic.cat
|
| Phone |
+34 932275400
|
| Organization name |
IDIBAPS
|
| Department |
Molecular Pathology Laboratory
|
| Lab |
Centre Esther Koplowitz (CEK)
|
| Street address |
Rosselló, 153
|
| City |
Barcelona |
| ZIP/Postal code |
08036 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL21558 |
[OncoScan_CNV] Affymetrix OncoScan CNV FFPE Assay |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA738923 |
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